MovDisordV3, Main, Exploration, bibRecord, 004146

Complex interactions in Parkinson's disease: A two‐phased approach

Identifieur interne : 004146 ( Main/Exploration ); précédent : 004145; suivant : 004147

Complex interactions in Parkinson's disease: A two‐phased approach

Auteurs : Demetrius M. Maraganore [États-Unis] ; Mariza De Andrade [États-Unis] ; Timothy G. Lesnick [États-Unis] ; Matthew J. Farrer [États-Unis] ; James H. Bower [États-Unis] ; John A. Hardy [États-Unis] ; Walter A. Rocca [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2003-06.

RBID : ISTEX:6D2F0F2002A2C9CA6122A9E865C7C8B5D95EB5E0

Descripteurs français

Pascal (Inist)
- Génotype, Homme, Méthode récursive, Parkinson maladie, Physiopathologie, Régression logistique, Ubiquitin thiolesterase, α-Synucléine.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Case-Control Studies, DNA Restriction Enzymes, Female, Genetic Predisposition to Disease, Genotype, Human, Humans, Ligases (genetics), Logistic Models, Logistic regression, Male, Movement Disorders (genetics), Mutation, Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pathophysiology, Polymerase Chain Reaction (methods), Recursive method, Synuclein, Synucleins, Thiolester Hydrolases (genetics), Ubiquitin Thiolesterase, Ubiquitin thiolesterase, Ubiquitin-Protein Ligases, alpha-Synuclein, epistasis, interactions, recursive partitioning, susceptibility genes, ubiquitin proteasome system.
MESH :
- chemical , genetics : Ligases, Nerve Tissue Proteins, Thiolester Hydrolases.
- chemical : DNA Restriction Enzymes, Synucleins, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligases, alpha-Synuclein.
- genetics : Movement Disorders, Parkinson Disease.
- methods : Polymerase Chain Reaction.
- Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Humans, Logistic Models, Male, Mutation.

Abstract

The identification of pathogenic mutations in the three genes α‐synuclein, parkin, and ubiquitin carboxy‐terminal hydrolase L1 (UCHL1) has elucidated the ubiquitin proteasome system (UPS) and its potential role as a causal pathway in Parkinson's disease (PD). In addition, polymorphisms of these three genes have been shown to be independently associated with PD. In a sample of 298 unrelated PD cases and 185 controls, we applied a two‐phased approach of recursive partitioning and logistic regression analyses to explore complex interactions. For women only, we observed an epistatic interaction of UCHL1 and α‐synuclein genotypes with significant effects on PD risk (odds ratio = 2.42; P = 0.003). Our findings are consistent with the hypothesis that PD is a multigenic disorder of the UPS. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/6D2F0F2002A2C9CA6122A9E865C7C8B5D95EB5E0/fulltext/pdf

DOI: 10.1002/mds.10431

Affiliations:

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<front><div type="abstract" xml:lang="en">The identification of pathogenic mutations in the three genes α‐synuclein, parkin, and ubiquitin carboxy‐terminal hydrolase L1 (UCHL1) has elucidated the ubiquitin proteasome system (UPS) and its potential role as a causal pathway in Parkinson's disease (PD). In addition, polymorphisms of these three genes have been shown to be independently associated with PD. In a sample of 298 unrelated PD cases and 185 controls, we applied a two‐phased approach of recursive partitioning and logistic regression analyses to explore complex interactions. For women only, we observed an epistatic interaction of UCHL1 and α‐synuclein genotypes with significant effects on PD risk (odds ratio = 2.42; P = 0.003). Our findings are consistent with the hypothesis that PD is a multigenic disorder of the UPS. © 2003 Movement Disorder Society</div>
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Movement Disorders (revue)

Complex interactions in Parkinson's disease: A two‐phased approach

Complex interactions in Parkinson's disease: A two‐phased approach

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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